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KMID : 0376219710080010075
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Chonnam Medical Journal
1971 Volume.8 No. 1 p.75 ~ p.83
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Mechanism of urinary excretion of I-malic acid in the dog
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Abstract
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In this study attempts to clarify the mechanism of urinary excretion of 1-malic acid was made in the dog by means of clearance method and stop-flow technique.
During malate infusion net reabsorption of the acid was, observed, while net secretion by the tubules was marked during succinate infusion. During malate infusion probenecid decreased the amount of malate excreted but did not markedly affect the amount of malate reabsorbed in the tubules. In experiments with succinate infusion, probenecid diminished the amount of malate secreted by the tubules and the clearance of the acid.
Stop flow experiment revealed that both the reabsorptive and secretory processes for malate are localized in the proximal portion of the nephron, and that the former process is not affected by probenecid, whereas the latter is partially inhibited by the agent. It is suggested from these observations that malate is reabsorbed in the proximal nephron by an active, energy-requiring, process, and secreted simultaneously in the proximal tubules at least partly by a probenecid sensitive, active process or by some mechanism mediated by carrier such as "facilitated diffusion."
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